✅ Product Benefits

• Dual mechanism for better glycemic control: Combines DPP‑4 inhibitor (Linagliptin) that enhances incretin hormones (GLP‑1 and GIP) to stimulate insulin release and reduce glucagon, with Metformin to decrease hepatic glucose output and increase insulin sensitivity. turn0search0turn0search7turn0search1

• Convenient fixed-dose formulation: Once- or twice-daily dose reduces pill burden and improves adherence over separate tablets. turn0search0turn0search8

• No dose adjustment in mild renal impairment: Linagliptin is minimally renally excreted—offers flexibility, though caution is still advised in advanced kidney dysfunction. turn0search7turn0search4

ℹ️ Dosage & Administration

• Standard regimen: 2.5 mg Linagliptin + 850 mg Metformin, taken with meals—usually once or twice daily depending on clinical guidance. Total daily Metformin limit: 2000 mg; Linagliptin max: 5 mg daily. turn0search0turn0search2

• Initiation strategy: For patients not on Metformin, begin with 500 mg and titrate upward to avoid gastrointestinal side effects. If already on Metformin, dose equivalence is maintained while adding Linagliptin. turn0search0turn0search2

⚠️ Side Effects & Precautions

• Common adverse effects: GI upset (nausea, diarrhea), nasopharyngitis, potential hypoglycemia when combined with sulfonylureas, tremors, dizziness. turn0search1turn0search2turn0search8

• Serious risks: Rare lactic acidosis risk from Metformin—especially in dehydration, renal/liver dysfunction, or acute illness. Monitor for abdominal pain, fatigue, rapid breathing. turn0search4turn0search2

• Contraindicated in: Renal impairment (eGFR low), metabolic acidosis including diabetic ketoacidosis, and in patients allergic to components. Not recommended during pregnancy or breastfeeding unless clinically essential. turn0search4turn0search1turn0search2

• Drug interactions: Rifampin and other P‑gp or CYP3A4 inducers may reduce Linagliptin effect. Caution with cationic drugs affecting renal elimination of Metformin. turn0search4turn0search2

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✅ Summary

Adlinameg 2.5 mg + 850 mg offers a convenient, effective combined therapy for adults with Type 2 Diabetes, especially those inadequately controlled on Metformin alone. By merging two complementary mechanisms, it improves glycemic regulation and simplifies dosing. As always, use under medical supervision with periodic monitoring.