💡 Uses & Benefits

• For relief of moderate to severe pain: post‑surgery, colic, cancer-related, joint, neck, back, and osteoporosis pain 

• Centrally acting analgesic that inhibits reuptake of serotonin and noradrenaline, and activates mu‑opioid receptors to modify pain transmission 

• Fast onset (typically 30–60 minutes after oral dose) with flexible dosing options from 50 to 100 mg every 4–6 hours

• Suitable for both acute and chronic pain relief, with total daily dose not exceeding 400 mg for safety 

⚠️ Use, Dosage & Safety

• Dosage: For chronic pain, start at 50 mg; acute pain may require initial 100 mg. Repeat every 4–6 hours as needed, not exceeding 400 mg/day

• Sustained‑release form available (100 mg SR): taken once every 12 hours with maximum daily dose of 400 mg

• Contraindications: Known hypersensitivity to tramadol, acute intoxication with alcohol, sedatives, opioids, or psychotropic drugs; avoid MAO inhibitors combinations 

• Side Effects: Common—dizziness, nausea, constipation, headache, drowsiness, vomiting, itching, dry mouth, diarrhea. Less common—weight loss, palpitations, GI or allergic reactions. May depress respiratory function at high doses or with CNS depressants 

• Warnings: Risk of opioid dependence with prolonged use; avoid combining with CNS depressants (e.g., alcohol, opioids); use cautiously with carbamazepine, head injury, high intracranial pressure, or respiratory risk patients