✅ Product Benefits

• Clinically-proven antihypertensive: As an angiotensin II receptor antagonist, irbesartan lowers blood pressure effectively and sustainably by blocking vasoconstrictive effects of angiotensin II. ([turn0search4]turn0search2]

• Renal protection in diabetic patients: Recommended for type 2 diabetic patients with nephropathy to reduce progression of kidney disease when used alongside blood pressure control. ([turn0search4]turn0search0]

• Convenient once‑daily dosing: Optimal starting dose is 150 mg once daily, with flexibility to titrate up to 300 mg/day as needed. Early initiation at 75 mg is advised for the elderly or volume-depleted patients. ([turn0search4]turn0search2]

• Elder-friendly regimen: Patients aged ≥75 or undergoing hemodialysis often begin with a reduced dose (75 mg), minimizing risk of hypotension. ([turn0search4]turn0search2]

• Cost-effective & widely available: Priced around ৳ 12 per tablet (~৳ 120 per strip of 10 or ৳ 360 per 30-pack); easily accessible across pharmacies in Bangladesh. ([turn0search1]turn0search6]

ℹ️ Dosage & Administration

• Tablet may be taken with or without food. Effect typically lasts about 24 hours. ([turn0search4]turn0search2]

⚠️ Safety, Side Effects & Warnings

• Common side effects: Dizziness, fatigue, gastrointestinal discomfort (nausea, dyspepsia), hyperkalemia (>19%), orthostatic hypotension (~5%), headache, diarrhea. ([turn0search4]turn0search1]

• Serious considerations:

  • Pregnancy contraindicated especially in the 2nd and 3rd trimesters—risks include fetal renal damage and skull hypoplasia. Discontinue immediately if pregnancy detected. ([turn0search0]turn0search5]

  • Avoid in lactation due to unknown risk. ([turn0search3]turn0search5]

  • Volume depletion & renal artery stenosis: administer only after correcting sodium and volume status. ([turn0search10]turn0search0]

  • Use caution in conditions like aortic/mitral stenosis, hypertrophic cardiomyopathy, or primary aldosteronism. ([turn0search0]turn0search10]

• Drug interactions:

  • NSAIDs may blunt antihypertensive effects and increase kidney risk.

  • Potassium-sparing diuretics, potassium supplements or salt substitutes raise hyperkalemia risk.

  • Lithium levels may increase—requires monitoring.

  • Avoid aliskiren in diabetic or renal-impaired patients due to risk of fatal outcomes. ([turn0search0]turn0search2]

• Overdose potential: May result in symptomatic hypotension or bradycardia/tachycardia—treatment is supportive; dialysis is not effective. ([turn0search0]turn0search6]

🧾 Quick Overview Table