✅ Product Benefits

• Effective blood pressure control: Irbesartan blocks angiotensin II AT₁ receptors to lower blood pressure by causing vasodilation and reduced aldosterone release. turn0search0turn0search2

• Renal protection in type 2 diabetes: At 300 mg daily, it's particularly recommended to slow progression of diabetic nephropathy. turn0search0turn0search4

• Convenient once-daily dosing: Starts at 150 mg daily; ups to 300 mg for better control—usually sufficient with long duration action. turn0search0turn0search2

• Well tolerated, minimal cough risk: Unlike ACE inhibitors, irbesartan has lower incidence of cough and generally fewer side effects. turn0search5turn0search7

ℹ️ Dosage & Administration

Initiating therapy with 75 mg may be appropriate in the elderly or during volume depletion. Pediatric use is not recommended due to limited data. turn0search2turn0search7

⚠️ Safety & Warnings

• Common side effects:

  • Dizziness, fatigue, GI upset, headache, and mild hyperkalemia (~19%). turn0search5

• Notable risks:

  • Hyperkalemia: Greater risk in diabetic or renal-impaired patients, especially when combined with potassium supplements or potassium-sparing medications. Regular potassium monitoring is advised. turn0search0turn0search1

  • Hypotension: May occur in volume-depleted individuals—correct dehydration or sodium–volume loss prior to initiation. turn0search0turn0search10

  • Pregnancy & lactation: Contraindicated especially in the second and third trimester due to fetal toxicity; not recommended during breastfeeding. turn0search5turn0search0

  • Special caution: In renal artery stenosis, valvular stenosis, hypertrophic cardiomyopathy, and primary aldosteronism. turn0search10turn0search1

• Drug interactions:

  • NSAIDs may blunt antihypertensive effect and increase renal risk.

  • Lithium toxicity may be increased.

  • Combined use with aliskiren in diabetic or renal disease patients is contraindicated. turn0search1turn0search5

• Overdose: May lead to severe hypotension or tachycardia; treat supportively. Activated charcoal may help; dialysis is ineffective. turn0search1turn0search10

📊 Quick Overview