✅ Product Benefits
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Once-daily extended-release convenience: A 4 mg ER capsule provides stable blood levels and sustained relief throughout the day for bladder symptoms. turn0search0turn0search7
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High bladder specificity with fewer systemic effects: Tolterodine preferentially targets bladder muscarinic receptors, minimizing dryness and sedation compared to non-selective anticholinergics. turn0search0turn0search11
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Rapid onset of symptom relief: Improvement may occur within 4 weeks of consistent use. turn0search11turn0search0
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Local availability at affordable cost: Widely available across Bangladesh, priced at approximately ৳ 15 per capsule (৳ 300 per 20-cap pack). turn0search0turn0search2
ℹ️ Dosage & Administration
| Patient Group | Recommended Dose |
|---|---|
| Adults ≥18 years | 4 mg once daily, with or without food |
| If side effects present | Reduce to 2 mg once daily |
| With CYP3A4 inhibitors / hepatic or renal impairment | Limit to 2 mg once daily |
| Pediatric use | Not recommended |
Swallow the capsule whole—do not chew or crush. Full therapeutic effect may take up to 4 weeks. turn0search0turn0search6
⚠️ Safety, Side Effects & Precautions
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Contraindications:
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Uncontrolled narrow-angle glaucoma
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Urinary retention or gastrointestinal obstruction (e.g., megacolon)
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Hypersensitivity to tolterodine or excipients turn0search0turn0search7
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Common side effects:
Dry mouth (~23 %), constipation, headache, dizziness, blurred vision, dry eyes. These anticholinergic effects are more common at therapeutic doses. turn0search0turn0search10 -
Cardiac and drug interaction warnings:
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Use cautiously in patients with known QT prolongation or taking QT‑prolonging drugs (e.g. antiarrhythmics).
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Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin, clarithromycin, protease inhibitors) significantly increase plasma levels—dose reduction to 2 mg advised. turn0search0turn0search7turn0search10
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Special populations:
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Elderly: No significant safety difference, but start at lower dose if needed.
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Renal/hepatic impairment: Use low dose (2 mg once daily); severe impairment contraindicated.
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Pregnancy & breastfeeding: Animal studies show potential risk; avoid unless benefit outweighs risk. Excretion in breast milk unknown—milk production may be reduced. turn0search0turn0search6
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Overdose: May result in severe anticholinergic symptoms (e.g., delirium, tachycardia)—ECG monitoring advised. turn0search10turn0search9
✔️ Quick Summary Table
| Feature | Details |
|---|---|
| Generic name | Tolterodine Tartrate 4 mg (extended-release) |
| Indication | Overactive bladder symptoms (urgency, frequency, urge incontinence) |
| Dose (adults) | 4 mg once daily (ER capsule) |
| Side effects | Dry mouth, constipation, dizziness, blurred vision |
| Major warnings | QT prolongation risk, urinary retention, CYP3A4 inhibitors |
| Approx. Price (BD) | ৳ 15 per capsule; ৳ 300 per 20-capsule pack |
| Manufacturer | UniMed UniHealth Pharmaceuticals Ltd., Bangladesh |
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