💡 Uses & Benefits

• Dual mechanism of action: Linagliptin inhibits DPP‑4 to enhance incretin hormone activity, boosting insulin secretion and lowering glucagon; Metformin reduces liver glucose production and increases insulin sensitivity. Together, they improve glycemic control effectively 

• Convenient dosing: One fixed-dose tablet simplifies treatment compared to taking component drugs separately 

• Flexible dosage adjustment: Can be titrated up to Linagliptin 5 mg/Metformin 1000 mg twice daily, depending on therapeutic needs 

• No renal dose adjustment needed for Linagliptin: Safe even in mild to moderate kidney impairment; Metformin requires caution in severe cases 

📋 Product Specifications

📌 Highlights at a Glance

• 💊 Two antidiabetic agents in one tablet for comprehensive glycemic control

• 🔄 Oral therapy with flexible doses to match patient needs

• ✅ Safe for mild-to-moderate renal impairment—no dose change needed for Linagliptin

• 🏭 Locally produced by Square Pharma, widely available across Bangladesh

⚠️ Uses & Precautions

• Take with meals to reduce GI side effects from Metformin  

• Monitor renal and liver function regularly; contraindicated in severe renal dysfunction (eGFR <30) or metabolic acidosis 

• Avoid alcohol and iodinated contrast agents due to risk of lactic acidosis  cite turn0search11 turn0search8 

• Common side effects include diarrhea, nausea, nasopharyngitis; hypoglycemia risk increases when used with sulfonylureas or insulin.

• Cases of acute pancreatitis have been reported—discontinue and evaluate if symptoms appear 

• Drug interactions: Reduced effectiveness with P‑gp/CYP3A4 inducers like rifampin; monitor when using cationic drugs that alter renal transport

🧠 User Advice

• Start with 2.5 mg Linagliptin/500 mg Metformin twice daily if not already on Metformin, then escalate as needed 

• Encourage diet and exercise to enhance efficacy.

• Patients should carry fast-acting sugar to manage potential hypoglycemia when used with insulin/SUs.

• Annual B₁₂ level checks recommended due to potential Metformin-related deficiency  cite turn0search8turn0search10

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