✅ Product Benefits & Highlights

• Effective therapy for PBC: Indicated for adults with primary biliary cholangitis without cirrhosis or with compensated cirrhosis (no portal hypertension), either as add-on to UDCA or as monotherapy in UDCA-intolerant patients. 

• Potent FXR agonist: Obeticholic Acid activates the Farnesoid X Receptor (FXR) to reduce bile acid production and improve bile acid clearance, reducing cholestasis and liver inflammation.

• Flexible dosing protocol: Usually starts at 5 mg once daily; if biochemical response is inadequate after 3 months, dose may be increased to 10 mg once daily. Annual dose adjustments and special regimens for cirrhosis (Child-Pugh B/C) are detailed. |

• Price & accessibility: Priced around ৳5.50 per tablet (৳55 for 10) and widely available in pharmacies and online platforms across Bangladesh. 

⚠️ Safety, Side Effects & Precautions

• Major side effects: High incidence of pruritus (intense itching, 56–70% at higher doses), fatigue, abdominal discomfort, rash, oropharyngeal pain, dizziness, constipation, abnormal thyroid tests, eczematous skin reactions. 

• Serious liver-related risk: Hepatic decompensation and liver failure—including fatal events—reported especially in cirrhotic patients who received doses beyond recommended levels. Monitoring of liver function and titration based on Child‑Pugh class is vital. 

• Drug interactions:

  • Bile acid–binding resins reduce OCA absorption—doses should be spaced ≥ 4 hours apart.

  • Co-administration with warfarin may lower INR; regular monitoring needed.

  • CYP1A2 substrates (e.g. theophylline, tizanidine) levels may increase—monitor carefully.

  • BSEP transporter inhibitors (e.g. cyclosporine) may worsen bile salt accumulation. 

• Contraindications: Avoid in decompensated cirrhosis (Child‑Pugh B or C), portal hypertension, or complete biliary obstruction. 

🧠 Why This SEO Strategy Works

• Covers both brand (“Livacol”) and generic (“Obeticholic Acid”) terminology to widen keyword reach.

• Targets PBC-specific terms (e.g., cholestasis, bile acid regulator) matched to patient searches in Bangladesh.

• Highlights Bangladesh-specific pricing, availability, and local manufacturer (Square Pharmaceuticals) to enhance local SEO visibility.

• Includes side effect, contraindication, and interaction keywords to address common queries and build trust.