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Product Benefits
| Core Benefit | Mechanism |
| Synergistic $\text{BP}$ Reduction | The combination leverages two different physiological pathways (blocking Angiotensin $\text{II}$ and reducing fluid volume) to achieve greater and more reliable blood pressure lowering than monotherapy. |
| Cardio- and Renal-Protective | Losartan ($\text{ARB}$) offers established cardiovascular protection and is particularly beneficial for diabetic patients with hypertension as it protects the kidneys. |
| Mitigates Potassium Loss | While $\text{HCTZ}$ can lower potassium, Losartan has a mild potassium-sparing effect, which helps to counteract and balance potential electrolyte loss. |
| Convenient Once-Daily Dosing | The fixed combination is taken once daily, significantly simplifying the treatment regimen and improving patient adherence for long-term chronic management. |
⚠️ Important Safety Note: $\text{ARB}$ Component
Prescription Required: This medication must be taken strictly as prescribed.
Fetal Toxicity (Black Box Warning): DO NOT use this medication if you are pregnant or planning to become pregnant. $\text{ARBs}$ can cause injury and death to the developing fetus, particularly during the second and third trimesters.
9 If pregnancy is detected, discontinue this medication immediately.Electrolyte Monitoring: Due to the diuretic component ($\text{HCTZ}$), your doctor will monitor your potassium, sodium, and uric acid levels regularly.
Gout Risk:
10 $\text{HCTZ}$ can increase uric acid levels, potentially exacerbating or triggering attacks of gout
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