✅ Product Benefits
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Effective in both schizophrenia and bipolar depression — Offers therapeutic flexibility: monotherapy or adjunct with lithium/valproate in bipolar depressive episodes, and standard therapy for schizophrenia
Dual receptor antagonism for efficacy — Acts on both dopamine D₂ and serotonin 5‑HT₂A receptors to help normalize mood and thought processes .
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Food-enhanced absorption — Bioavailability significantly increases when taken with at least 350 calories, improving effectiveness
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Flexible dosing strategy — For bipolar depression: start at 20 mg once daily (max 120 mg/day); for schizophrenia: start at 40 mg once daily, up to 160 mg/day, without need for titration .
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Guided dose adjustments in organ impairment — Renal impairment (CrCl <50 mL/min): max 80 mg/day; severe hepatic impairment: max 40 mg/day .
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Well‑documented safety and monitoring guidelines — Common side effects include somnolence, akathisia, extrapyramidal symptoms, nausea; monitor CBC and metabolic markers due to risks like weight gain, hyperglycemia, leukopenia, orthostatic hypotension, and tardive dyskinesia .
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Pregnancy category B — Use in pregnancy only if benefits justify risks; breastfeeding may expose infant to drug—consult healthcare provider .
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