💡 Uses & Benefits

• Relieves nausea, vomiting & indigestion symptoms associated with dyspepsia, gastritis, gastroparesis, and functional GI disorders 

• Enhances gastric motility, speeding gastric emptying to reduce bloating and fullness 

• Acts peripherally on dopamine receptors, minimizing central nervous system side effects such as sedation or drowsiness

• Helps radiology patients, improving movement of barium and other contrast agents through intestinal tract 

📋 Dosage & Administration

• Maximum treatment duration should typically not exceed 12 weeks unless advised by physician 

⚠️ Side Effects & Precautions

• Common side effects: headache, dry mouth, abdominal discomfort, diarrhea, drowsiness, dizziness 

• Less common/rare effects: galactorrhea, gynecomastia, decreased libido, extrapyramidal symptoms (especially in young children), skin rash, constipation, allergic reactions, and cardiac arrhythmias in high-risk patients

• Precautions:

  • Avoid use in neonates, known prolactin-releasing pituitary tumors, GI obstruction, perforation, or hemorrhage

  • Use caution in children (<2 yr), elderly, or patients with liver/kidney impairment due to higher risk of side effects

🧪 Drug Interactions & Contraindications

• Contraindicated in those with known hypersensitivity to domperidone or significant GI obstruction/bleeding/perforation or prolactinoma

• Use caution or avoid co-use with MAO inhibitors, opioid analgesics, anticholinergics, and CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) which may raise domperidone levels and increase QT-prolongation risk

🤰 Pregnancy & Lactation

• Not recommended during pregnancy—animal studies show potential fetal risk; human safety not established

• Breastfeeding: Domperidone passes into breastmilk in low amounts; may increase prolactin levels and lactation—but advise caution and medical supervision

🏷 Product Details (Bangladesh Market)

• Generic Name: Domperidone

• Brand Name: Motigut 10 mg Tablet

• Manufacturer: Square Pharmaceuticals Ltd.

• Price: Approx. ৳0.40–0.50 per tablet; strip of 10 ≈ ৳4–5 BDT 

• Form: Film-coated tablet

• Storage: Dry place, <30 °C, away from direct light and moisture

🔍 Quick Benefits Summary

• Fast relief from nausea, vomiting, fullness, and indigestion symptoms

• Promotes digestive motility, reducing gastric stasis and reflux

• Non-centrally acting, minimizing sedation or neurological effects

• Convenient pre-meal dosing schedule with affordable cost