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Product Benefits
| Core Benefit | Mechanism |
| Dual Efficacy and Protection | Combines the potent anti-inflammatory effects of Naproxen with the gastric acid suppression of Esomeprazole, ensuring effective pain management without compromising stomach safety. |
| Sustained Pain Relief | Naproxen is a long-acting $\text{NSAID}$, providing sustained analgesic relief and often requiring less frequent dosing than other $\text{NSAIDs}$. |
| Prevents Gastric Ulcers | Esomeprazole acts as a proton pump inhibitor, blocking the final step of acid production and dramatically reducing the risk of ulcers and gastric bleeding caused by the Naproxen component. |
| Convenient Dosing | The fixed combination offers the ease of taking two essential medications (pain reliever and stomach protector) in a single tablet, improving patient adherence. |
⚠️ Critical Safety Note: $\text{NSAID}$ and $\text{PPI}$ Combination
Prescription Required: This medication must be taken strictly as prescribed.
Cardiovascular Risk (Black Box Warning): $\text{NSAIDs}$ like Naproxen may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction ($\text{MI}$/heart attack) and stroke. This risk may increase with duration of use.
Gastrointestinal Risk (Black Box Warning): $\text{NSAIDs}$ can cause serious $\text{GI}$ adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Do not take other $\text{NSAIDs}$ or Aspirin with this medication unless directed by your doctor.
$\text{CABG}$ Surgery: This medication is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft ($\text{CABG}$) surgery.
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