✅ Product Benefits

• Effective PDE‑5 inhibitor: Sildenafil enhances nitric oxide–mediated vasodilation in penile tissue, improving erection firmness and duration during sexual stimulation. It also relaxes pulmonary vessels to support exercise capacity in PAH patients. ([turn0search2]turn0search0])

• Flexible dosing window: Take 25–100 mg orally, approximately 30 minutes to 4 hours prior to activity, based on response; maximum one dose per 24 h. PAH dosing: 20 mg TID, spaced 4–6 hours apart. ([turn0search4]turn0search3])

• Rapid onset & convenience: Effects often begin within 1 hour and sustained for several hours. Tablets can be taken with or without food. ([turn0search3]turn0search0])

• Low cost & local availability: Priced around ৳ 20 per tablet (strip of 4 for ৳ 80), making it one of the most accessible ED therapy options in Bangladesh. Available OTC in many pharmacies. ([turn0search1]turn0search9])

ℹ️ Safety & Precautions

• Contraindications:

  • Avoid concurrent use with organic nitrates or nicorandil due to risk of severe hypotension.

  • Not for patients with hypersensitivity to sildenafil. ([turn0search0]turn0search3])

• Main side effects: Common (>10%)—headache, flushing, dyspepsia; others 1–10%—nasal congestion, insomnia, dizziness, visual disturbances (blue-green tint), diarrhea, muscle pain. Rare serious effects include hypotension, arrhythmia, myocardial ischemia. ([turn0search3]turn0search8])

• Drug interactions:

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) significantly increase sildenafil levels (up to 11× AUC), raising risk of adverse effects.

  • CYP3A4 inducers (e.g., rifampin, bosentan) may reduce efficacy.

  • Beta‑blockers may enhance hypotensive effects; warfarin, ACE inhibitors, SSRIs have minimal effect. ([turn0search0]turn0search1])

• Special populations:

  • For patients aged ≥65 or with hepatic/renal impairment or severe renal disease (CrCl <30 mL/min): initiate with 25 mg and adjust.

  • Not indicated in women; pregnancy and breastfeeding not recommended without physician consult. ([turn0search3]turn0search1])

• Warnings & rare risks:

  • Priapism: Seek emergency care if erection lasts >4 hours.

  • Sudden hearing or vision loss, hypotension, syncope, heart events reported rarely—monitor high-risk patients. ([turn0search0]turn0search8])

🧾 Dosing Summary

🔍 At-a-Glance Overview

• Active ingredient: Sildenafil citrate

• Mechanism: PDE‑5 inhibition → ↑cGMP → vasodilation

• Onset: ~30 min–1 h; Duration: up to 4–6 h

• Pricing: ~৳ 20 per tablet (strip of 4 ≈ ৳ 80)

• Availability: Widely available over-the-counter in Bangladesh per regulatory rules with physician oversight. ([turn0search1]turn0search2])