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Product Benefits
| Core Benefit | Mechanism |
| Consistent Angina Prophylaxis | The Sustained-Release (Retard) mechanism ensures a continuous release of the low dose, providing stable plasma concentrations to protect against chronic anginal attacks throughout the day. |
| Reduces Cardiac Oxygen Demand | Primarily through venous dilation, it lowers the amount of blood returning to the heart (preload), effectively reducing the workload and subsequent oxygen demand of the heart muscle. |
| Improves Coronary Blood Flow | Relaxation of the coronary arteries helps to increase blood flow and oxygen delivery to the areas of the heart muscle that are ischemic (oxygen-starved). |
| Prophylactic Therapy | Used regularly as part of a treatment regimen, it helps to significantly decrease the frequency and severity of chronic chest pain episodes. |
⚠️ Critical Safety Note: Nitrate Medication
Acute Attack Warning: This sustained-release tablet is NOT SUITABLE for treating an acute, ongoing anginal attack.
8 For immediate relief, a rapidly acting Nitroglycerin formulation (e.g., sublingual tablet or spray) is required.$\text{PDE}5$ Inhibitor Contraindication: DO NOT TAKE this medication if you are taking or have recently taken
9 $\text{PDE}5$ inhibitors (medications for erectile dysfunction or pulmonary hypertension) such as Sildenafil, Tadalafil, or Vardenafil.10 This combination is highly dangerous and can cause a severe, life-threatening drop in blood pressure.Nitrate-Free Interval: To prevent the body from developing drug tolerance (tachyphylaxis), doctors typically prescribe a nitrate-free interval (e.g., $8$-$12$ hours off the drug daily) to restore responsiveness. Follow your doctor's exact dosing schedule.
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