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Product Benefits
| Core Benefit | Mechanism |
| Sustained Angina Prevention | The Retard (sustained-release) formulation ensures slow and steady release of Nitroglycerin, providing prolonged prophylactic action to significantly reduce the frequency and severity of chronic anginal attacks. |
| Reduces Cardiac Workload | By causing venous dilation, it pools blood peripherally and reduces the volume of blood returning to the heart (preload), significantly decreasing myocardial oxygen demand. |
| Improves Blood Supply | Vasodilation of the coronary arteries improves the supply of oxygen-rich blood to the heart muscle, counteracting the imbalance that causes ischemic chest pain. |
| Convenient Dosing | The sustained-release property allows for less frequent dosing (often twice daily), which is convenient for the long-term management of chronic $\text{CAD}$. |
⚠️ Critical Safety Note: Nitrate Medication
Prescription Required: This medication must be taken strictly as prescribed.
$\text{PDE}5$ Inhibitor Contraindication: DO NOT TAKE this medication if you are taking or have recently taken
11 $\text{PDE}5$ inhibitors (medications for erectile dysfunction or pulmonary hypertension) such as Sildenafil, Tadalafil, or Vardenafil.12 This combination can cause a life-threatening, severe drop in blood pressure (profound hypotension).Tolerance (Refractory Period): To prevent the body from developing tolerance to the drug (which reduces its effectiveness), physicians often prescribe a daily "nitrate-free interval" (a period of $8$-$12$ hours where the patient does not take the drug).
Side Effects: Common side effects include headache (often severe, indicating the drug is working) and flushing. Report persistent or severe hypotension (dizziness, fainting) to your doctor.
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