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Product Benefits
| Core Benefit | Mechanism |
| Effective Anti-Emetic Action | Blocks dopamine receptors in the $\text{CTZ}$, the brain area that triggers vomiting, providing reliable prevention and relief of nausea and vomiting from various causes. |
| Accelerates Gastric Emptying | As a prokinetic, it improves the movement of food from the stomach into the small intestine, relieving symptoms of gastric stasis (delayed emptying) like fullness, belching, and bloating. |
| Low Central Nervous System ($\text{CNS}$) Effects | Due to its relatively poor penetration of the blood-brain barrier, it generally causes fewer $\text{CNS}$ side effects (like drowsiness or movement disorders) compared to some other anti-emetics. |
| Relieves Reflux Symptoms | By increasing the tone of the lower esophageal sphincter, it helps to reduce the backward flow of stomach contents (reflux), complementing therapy for $\text{GERD}$. |
⚠️ Critical Safety Note: Cardiac Risk
Prescription Required: This medication must be taken strictly as prescribed.
Cardiac Risk: Domperidone has been associated with a small increased risk of serious ventricular arrhythmias and sudden cardiac death.
12 It should be used at the lowest effective dose for the shortest duration possible.13 Contraindications: It is contraindicated in patients with moderate to severe hepatic (liver) impairment and in those with existing heart conditions (e.g.,
14 $\text{QT}$ interval prolongation, heart failure).15 Administration: It is typically recommended to take this tablet 15-30 minutes before meals to optimize its prokinetic effect.
16
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