• Potent and sustained acid suppression: Pantoprazole irreversibly inhibits H⁺/K⁺-ATPase in gastric parietal cells, significantly reducing both basal and stimulated acid secretion for over 24 hours

• Broad therapeutic uses:

  • Heals peptic and duodenal ulcers (40 mg once daily for up to 4 weeks, extendable to 8 weeks if needed).

  • Manages GERD and erosive esophagitis, with standard treatment at 20–40 mg daily for 4–8 weeks; maintenance dosing at 20 mg daily as needed

  • Prevents NSAID-induced ulcers with once-daily 20 mg in long-term NSAID users.

  • Used in H. pylori eradication regimens in combination with antibiotics like amoxicillin and clarithromycin or metronidazole

  • Treats Zollinger‑Ellison syndrome, with flexible dosing starting at 80 mg and titrated per acid suppression response.

• Convenient once-daily dosing: Taken in the morning on an empty stomach; enteric coating prevents degradation in stomach acid. Tablets should not be crushed or chewed

• Affordable and widely accessible: Priced around ৳ 3 per tablet (৳ 30 per strip), making it an economical PPI option in Bangladesh.

ℹ️ Precautions & Safety Notes

• Side effects: Generally well tolerated. Common reactions include headache, diarrhea, abdominal discomfort, flatulence, constipation, insomnia, or rash.

• Long‑term use concerns: Extended therapy may increase the risk of osteoporosis-related fractures, hypomagnesemia, vitamin B₁₂ deficiency, and Clostridioides difficile infection. Periodic monitoring and supplementation with calcium/vitamin D are advisable

• Drug interactions: May affect absorption or metabolism of certain drugs such as warfarin, ketoconazole, clopidogrel, and others via CYP pathways. Monitor for interaction effects

• Contraindications: Avoid in patients with known hypersensitivity to pantoprazole or other proton pump inhibitors. Use cautiously in severe liver impairment, pregnancy, and lactation only if clearly needed.

• Missed dose instructions: If a dose is missed, take it as soon as remembered unless it's near the next dose; do not double-dose.