✅ Product Benefits

• Selective bronchodilation with improved safety
  Doxofylline selectively inhibits phosphodiesterase‑4 to relax bronchial smooth muscle. Unlike theophylline, Pulmodox has minimal binding to adenosine A1/A2 receptors and thus is associated with fewer CNS/cardiac side effects. turn0search0turn0search1turn0search3

• Antiinflammatory and antiplatelet properties
  Additional actions include inhibiting leukotriene and platelet activating factor (PAF), helping reduce airway inflammation and hyperreactivity. turn0search0turn0search3

• Flexible dosing for multiple populations

  • Adults: 200 mg tablet 2–3 times daily; or 400 mg divided if needed.

  • Elderly: 200 mg 2–3 times daily.

  • Children > 12 years: 200 mg tablet (or syrup) 2–3 times daily.

  • Children (6–12 years): ~6–9 mg/kg twice daily.
    SR formulation available for once-daily dosing when 400 mg is required. turn0search2turn0search9turn0search6

• Affordable & locally accessible
  Priced around ৳ 6–8 per tablet (~৳ 60–80 per 10‑tablet strip), Pulmodox is widely available in Bangladesh. turn0search1turn0search4

ℹ️ Dosage & Administration

If a total of 400 mg is required, once‑daily SR formulation may be more convenient. Tablets can be taken with or without food. turn0search3turn0search7

⚠️ Safety & Precautions

• Contraindications
  Not recommended in patients with known hypersensitivity to doxofylline, acute myocardial infarction, hypotension, or in lactating women. turn0search0turn0search3

• Side effects (generally mild and caffeine-like)
  May include nausea, vomiting, abdominal discomfort, headache, irritability, insomnia, tachycardia, extrasystoles, rapid breathing. Rarely hyperglycemia or albuminuria. Overdose can lead to seizures or arrhythmias. turn0search3turn0search6turn0search7

• Drug interactions
  Avoid co-use with other xanthines; caffeine, ephedrine, sympathomimetics may potentiate effects. Antibiotics like erythromycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and flu vaccine can reduce hepatic clearance and elevate levels. Smoking and anticonvulsants may increase clearance, requiring dose adjustments. turn0search6turn0search7

• Special precautions
  In liver disease, congestive heart failure, COPD, older age, monitor dosing carefully. Adjust dose as needed in patients with reduced clearance. turn0search3turn0search6

• Pregnancy & lactation
  Animal studies show no fetal harm but limited human data; use only if clearly needed. Contraindicated during breastfeeding. turn0search0turn0search3

📄 Summary Table