✅ Product Benefits
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Effective UTI therapy: Specifically indicated for uncomplicated UTIs, inhibiting bacterial ribosomal proteins and key macromolecules in susceptible pathogens. Useful against E. coli, Enterococcus faecalis, Staph. saprophyticus, Klebsiella, and Enterobacter. ([turn0search0]turn0search3]
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Well-tolerated macrocrystal form: Nitrofurantoin macrocrystals tend to cause less gastrointestinal irritation than some other formulations; predictable pharmacokinetics in urine.
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Flexible dosing options: Comes in 50 mg and 100 mg capsules, plus suspension form, allowing tailored therapy for adults and children. ([turn0search0]turn0search3]turn0search2]
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Affordable local brand: Priced at approximately ৳ 8 per capsule (~৳ 80 for a strip of 10), making it accessible within Bangladesh’s healthcare market. ([turn0search0]turn0search1]
ℹ️ Indications & Dosing Guide
| Patient Group | Indication | Dosage | Duration |
|---|---|---|---|
| Adults (acute uncomplicated UTI) | Cause: E. coli, staph, enterococci, others | 50–100 mg capsule 4×/day | 7 days or ≥3 days post‑sterility |
| Adults (long-term suppression) | Recurrent UTI prevention | 50–100 mg once daily | As prescribed |
| Surgical prophylaxis | Genito-urinary surgery | 50 mg 4×/day during procedure + 3 days | Until 3 days after procedure |
All formulations: take with food to reduce nausea, swallow whole. Therapy should continue per regimen even if symptoms improve. ([turn0search0]turn0search3]turn0search2]
⚠️ Safety & Precautions
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Contraindications: Severe renal impairment (CrCl very low), anuria or oliguria, hypersensitivity to nitrofurantoin, and late pregnancy (38–42 weeks) or labor/breastfeeding infants (<1 month). ([turn0search0]turn0search3]
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Common side effects: May include nausea, headache, flatulence, diarrhea, dyspepsia, abdominal discomfort, constipation, dizziness, drowsiness. Urine often becomes dark yellow or brown—typically harmless. ([turn0search0]turn0search3]turn0search2]
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Serious adverse effects (rare): Pulmonary hypersensitivity reactions, hepatotoxicity, peripheral neuropathy, hemolytic anemia in G6PD deficiency. Discontinue if any unusual symptoms arise. ([turn0search0]turn0search3]
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Drug Interactions: Antacids containing magnesium trisilicate can reduce absorption. Probenecid and sulfinpyrazone reduce renal excretion. Avoid concurrent administration. ([turn0search0]turn0search3]
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Pregnancy & breastfeeding: Category B; only use if clearly needed. Trace amounts may pass into breastmilk—avoid in infants <1 month. ([turn0search0]turn0search3]
📝 Summary Table
| Feature | Details |
|---|---|
| Generic name | Nitrofurantoin macrocrystals 100 mg |
| Formulation | Macrocrystal capsule for UTI treatment |
| Indications | Uncomplicated UTI, prophylaxis, surgical UTI prophylaxis |
| Typical adult dose | 50–100 mg capsules 4×/day |
| Common side effects | GI upset, headache, brown urine |
| Warnings | Pulmonary, hepatic, neuropathy; not for late pregnancy or infants |
| Price (BD) | ~৳ 8 per capsule; ±৳ 80 per 10-capsule strip |
| Manufacturer | UniMed UniHealth Pharmaceuticals Ltd., Bangladesh |
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