✅ Product Benefits
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High‑potency triazole antifungal
Inhibits fungal 14‑α sterol demethylase to disrupt ergosterol synthesis, effectively targeting invasive and resistant fungal pathogens like Aspergillus, Candida, Fusarium, and Scedosporium -
Standardized dosing with loading regimen
For patients ≥40 kg: loading dose 400 mg every 12 hrs for the first 24 hrs, followed by maintenance of 200 mg every 12 hrs. For patients <40 kg: maintenance dosage is 100 mg twice daily -
Actively indicated for life‑threatening fungal infections
Used against invasive aspergillosis, severe candidiasis (including bloodstream and esophageal forms), and infections from rare molds in immunocompromised patients -
Excellent oral absorption & bioavailability
Tablet has nearly 100% oral bioavailability, allowing seamless switch between IV and oral therapy without dose adjustment -
Key safety considerations
Common side effects: nausea, abdominal pain, blurred vision, headache, elevation of liver enzymes, chest discomfort, and rash. May rarely cause QT prolongation, visual disturbances, or skin sensitivity with prolonged exposure (>180 days) Significant drug interactions Metabolized via CYP3A4, CYP2C9, and CYP2C19—dose adjustments or monitoring required when co-administered with inhibitors/inducers like phenytoin, efavirenz, rifampin, ritonavir, warfarin, and others
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Renal/hepatic guidance included
No dose adjustment needed in mild to moderate renal impairment; in mild–moderate hepatic dysfunction (Child A/B), maintenance dose should be reduced by 50%. Use with caution in severe liver disease . -
Widely available & priced affordably
Pack of 10 tablets priced around ৳1000 (৳100 per tablet); manufactured and distributed across Bangladesh by Square Pharmaceuticals
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